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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GRHL2
All Species:
22.73
Human Site:
S281
Identified Species:
50
UniProt:
Q6ISB3
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ISB3
NP_079191.2
625
71105
S281
Q
F
Y
A
I
T
L
S
E
T
G
D
N
K
C
Chimpanzee
Pan troglodytes
XP_519890
707
80000
S363
Q
F
Y
A
I
T
L
S
E
T
G
D
N
K
C
Rhesus Macaque
Macaca mulatta
XP_001098439
625
71123
S281
Q
F
Y
A
I
T
L
S
E
T
G
D
N
K
C
Dog
Lupus familis
XP_849137
625
71103
S281
Q
F
Y
A
I
T
L
S
E
T
G
D
N
K
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8K5C0
625
71177
S281
Q
F
Y
A
I
T
L
S
E
T
G
D
N
K
C
Rat
Rattus norvegicus
NP_001127999
626
71242
S282
Q
F
Y
A
I
T
L
S
E
T
G
D
N
K
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508924
561
63479
G241
K
Y
R
S
A
S
V
G
A
E
E
Y
I
Y
E
Chicken
Gallus gallus
XP_426209
631
72101
K299
Q
F
Y
P
I
T
L
K
E
V
S
S
S
E
G
Frog
Xenopus laevis
Q5EY87
609
69713
N281
T
L
K
E
I
G
S
N
K
G
I
H
H
P
I
Zebra Danio
Brachydanio rerio
NP_001076541
554
63238
R235
R
H
P
I
S
K
V
R
S
V
V
M
V
V
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13002
1333
143896
L935
G
Q
F
Y
G
I
T
L
E
Y
V
H
D
A
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.2
98.4
96.4
N.A.
94.7
94.5
N.A.
77.7
57.3
58.4
65.1
N.A.
20.5
N.A.
N.A.
N.A.
Protein Similarity:
100
88.2
98.7
97.7
N.A.
97.2
97.1
N.A.
83
71.4
74
75.5
N.A.
31.8
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
46.6
6.6
0
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
60
26.6
13.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
55
10
0
0
0
10
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
55
10
0
0
% D
% Glu:
0
0
0
10
0
0
0
0
73
10
10
0
0
10
19
% E
% Phe:
0
64
10
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
10
0
0
0
10
10
0
10
0
10
55
0
0
0
10
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
19
10
0
0
% H
% Ile:
0
0
0
10
73
10
0
0
0
0
10
0
10
0
10
% I
% Lys:
10
0
10
0
0
10
0
10
10
0
0
0
0
55
0
% K
% Leu:
0
10
0
0
0
0
64
10
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
55
0
0
% N
% Pro:
0
0
10
10
0
0
0
0
0
0
0
0
0
10
0
% P
% Gln:
64
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
10
10
10
10
55
10
0
10
10
10
0
0
% S
% Thr:
10
0
0
0
0
64
10
0
0
55
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
19
0
0
19
19
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
64
10
0
0
0
0
0
10
0
10
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _